Duratia, which is a brand name for the medication containing the active ingredient dapoxetine, is primarily used to treat premature ejaculation. It's important to note that dapoxetine is a selective serotonin reuptake inhibitor (SSRI) used for this specific purpose and not for depression or anxiety, as SSRIs are typically used. Antihistamines, on the other hand, are used to relieve allergy symptoms, and they work by blocking histamine receptors in the body. There’s no widely known or significant interaction between Duratia (dapoxetine) and antihistamines. However, both types of medications can have side effects, and the overall effect can vary from person to person. For instance, some antihistamines can cause drowsiness, and if you’re taking other medications or have underlying health conditions, it’s always a good idea to discuss potential interactions with your healthcare provider. If you have specific concerns about the medications you’re taking, including any potential interactions, your healthcare provider or pharmacist is the best source for personalized advice.