Zhewitra 40 mg contains vardenafil as its active ingredient, which is a phosphodiesterase type 5 (PDE5) inhibitor. There is no direct evidence to suggest that vardenafil, the active ingredient in Zhewitra 40mg, has a significant effect on testosterone levels. PDE5 inhibitors like vardenafil primarily work by increasing blood flow to the penis, which can help men achieve and maintain erections. They do not directly affect hormone levels such as testosterone. Testosterone levels are primarily regulated by the hypothalamus and pituitary glands in the brain, which signal the testes to produce testosterone. Factors such as age, health conditions, lifestyle, and medications can influence testosterone levels, but there is no direct link between PDE5 inhibitors and testosterone levels. If you have concerns about testosterone levels or erectile dysfunction, it's important to discuss them with a healthcare professional who can provide personalized advice and treatment options based on your individual health status and needs.